本剧讲述了在国外行医多年的女心外科医生唐佳瑜，被副院长刘沣邀请回国担任北京安和济生医院心脏中心的主任。从与医务处处长欧阳真予不打不相识，到与麻醉科医生叶弈明渐渐发展为知己。同时又带领重病组五位成员：江百列、龙向东、秦大中、周达、廖小波共同救治28起罕见心脏病例，在不断的成长中助推了国产“全磁悬浮人工心脏”的成功研发，最终改写了中国心外历史，同时实现自我救赎，收获幸福的故事。
叶小白（陈都灵 饰）久久无法走出失恋的阴云，为了鼓励女儿，叶小白的母亲病急乱投医，给叶小白安排了各种相亲活动，叶小白在此期间屡屡遭遇奇葩男，对待爱情更加的心灰意冷。为了逃避感情的不顺，叶小白将全部的心思都投入到了工作中，她加入了上司管一鹤（刘恺威 饰）负责的一个上市项目中，两人之间的距离因此而渐渐拉近。随着时间的推移，叶小白和管一鹤相恋了。然而，在这家公司里，同事之间是不被允许发展恋爱关系的，更何况是像他们这样的上下级关系。无奈之下，叶小白和管一鹤只得将这段恋情转入地下，这让叶小白受了很多的委屈，她的爱情之路也因此变得崎岖起来。
LIFE ON TOP is a new erotic television series exploring the sex-filled adventures of four young women striving to make it in Manhattan. Sophie, an ambitious but na?ve business school graduate who just broke up with her college boyfriend, moves to New York intent on making her mark at a venture capital firm. She's shocked when she arrives at her older sister Bella's fabulous city apartment and discovers that gorgeous, confident and outgoing Bella is also a very successful and much in demand erotic model with plenty of scandalous secrets to reveal. But Bella, who is not as tough as she seems, is also facing the reality of the limited lifespan of her beauty-obsessed profession and yearning for a more stable and meaningful relationship with that one special person. While Sophie is still burdened with some old-fashioned ideas about sexuality, she's also envious of Bella's glamorous, liberated girl-about-town lifestyle. And then there's all those beautiful new people she'll get to meet. There's so much more to learn about life and love from an ever-expanding group of vibrant, sexually-charged girlfriends and the men who hover around them. LIFE ON TOP is based on the upcoming St. Martin's novel by Clara Darling.
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