该剧翻拍自日本人气电视剧《昼颜》，讲述因为禁断的爱而经历残酷体验的成年人们的成长电视剧。由《坏家伙们》导演金政民执导，刘素静编剧执笔。
公元712年，唐睿宗改元延和，大唐依旧繁盛寰宇，但繁华之下依然危机四伏、山雨欲来。一股股势力借机点点欲动，更引起民间诡案频发，大理寺少卿卢凌风（杨旭文 饰）和乾陵丞苏无名（杨志刚 饰）又将遇到怎样的志怪谜局？西行之路，境遇难测。
This drama is set in a south Florida plastic surgery center, McNamara-Troy, centering around the two doctors who own it. Sean McNamara (Dylan Walsh) is having problems at home, trying to keep his family together, trying to patch up the rocky road him and his wife Julia (Joely Richardson) are experiencing. On the other hand, sex-craved Christian Troy (Julian McMahon) uses his charm to bring in potential female candidates and conducts shady business deals, often for the love of money. While Sean takes his job seriously, he often has to fix Christian's mistakes. During the first season, Sean and Christian got mixed up with Escobar Gallardo, a Colombian drug lord who forced the two to do free surgery whenever he wanted them to. Sean's marriage with Julia began to wear thin, and Sean had an affair with a patient named Megan O'Hara. Julia went back to school, but it was interrupted by a miscarriage of a child Sean and Julia were trying to have. Christian learned he is the father of a baby with a woman named Gina, who he met at Sexaholics Anonymous. When the baby was born, we learn that the baby is African-American, and therefore not his. Julia questions Matt's paternity.
天宫武财神（陈浩民 饰）受玉帝（卢勇 饰）差遣，奉旨下凡普度众生，不料遭蟾族陷害追杀，被化成人形的小狐狸（穆婷婷 饰）搭救。他因此与雪山巫女、小狐狸和贪心的黒面道士产生了纠纷，双方剑拔驽张，展开了血雨腥风的搏杀。最终，雪山巫女与黒面道士双双气绝身亡。狐王（倪齐民 饰）时年已999岁，再有一年便羽化成仙，他要自己衷爱的女儿九妺（穆婷婷 饰）嫁给金不换（谭耀文 饰），以期将来传位于她，结果遭到八个姐姐的反对与妒嫉。而九妹并不喜欢父王钦点的金不换，她想伺机逃走，看破她心思的狐王把九妺囚禁了起来，九妹冲破金不换的层层设防，最终走向自由。樵夫刘枫（陈浩民 饰）偶遇落难的九妹，两人一见钟情…
西汉宣帝时期，王夫人和淳于夫人都是后宫女医，后二人被利用，最终一个自尽一个被问斩。淳于夫人之女淳于瑶（桑叶红 饰）亲眼看着母亲和姐姐惨死，由此对王夫人的女儿王政君（袁立 饰）就此埋下了仇恨种子。十五年后，当年的两个小女孩都长成了亭亭玉立的少女，王政君和改名为傅瑶的淳于瑶都被选为家人子，同期的家人子还有冯媛（孙茜 饰）、王昭君（白庆林 饰）、李元儿（石小群 饰）。一次偶然的机会，五人邂逅了一位老妪，她预言说在这五个女孩中将会诞生一位皇后。从此，五个女孩心中都埋下了各自的心事……皇后宝座只有一个，谁是幸运儿？ 当年埋下的仇恨是否能够化解？
《使女的故事》第二季确定2018年4月回归，总共会有13集。
